Platelet and cancer, platelet-based markers are potentialĬandidates for the diagnosis and follow-up of gastric cancer.Įlevated mean platelet volume (MPV) of peripheral blood has been Of platelets is increased by proinflammatory cytokines released byĬancer cells through the promotion of megakaryocyte proliferation Platelets play an important and multifaceted role inįindings suggested that platelets accelerate the natural course ofĬancer by promoting neoangiogenesis, degradation of theĮxtracellular matrix, release of adhesion molecules, and growthįactors, thus providing essential components for tumor growth and Of novel biomarkers for the diagnosis and follow-up of gastric These biomarkers have a low diagnostic ability to detect gastric Survival rate is only 10–15% in individuals with advanced diseaseĬrucial, especially given that early symptoms (dyspepsia, mildĮpigastric pain, nausea, and anorexia) are not very specific.īiomarkers including, CEA and CA 19-9, have been tested. Patients are able to undergo surgical resection. Principal cause of increased mortality and morbidity associated The second most common cause of cancer-related mortalities Gastric cancer is the fourth most common cancer and In conclusion, MPV measurement can provide important diagnostic and prognostic results in patients with resectable gastric cancer. Multivariate Cox regression analysis revealed that the depth of invasion, lymphonodus metastasis, American Joint Committee on Cancer (AJCC) stage, and changes in MPV following surgery were prognostic factors affecting OS, and the AJCC stage and pre-operatic MPV were prognostic factors affecting DFS. The patients whose MPV level decreased following surgery had an improved OS. Surgical tumor resection resulted in a significant decrease in the MPV level. The Kaplan-Meier plots showed that the patients with higher pre-operatic MPV had decreased overall survival (OS) and disease-free survival (DFS). Low pre-operatic MPV level correlated with improved clinicopathological features, including decreased depth of invasion, less lymphonodus metastasis and early tumor stage. The results showed that the pre-operatic MPV level was significantly higher in gastric cancer patients compared with the healthy subjects. In total, 168 patients with resectable gastric cancer were included and separated into the gastric cancer and healthy control groups according to median pre-operatic MPV value (MPV low, <10.51 or MPV high, ≥10.51). In the present study, we investigated the application value of MPV in early diagnostic and prognostic prediction in patients with resectable gastric cancer. Elevated mean platelet volume (MPV) detected in peripheral blood has been identified in various types of cancer. Platelets play an important and multifaceted role in cancer progression. Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related mortalities worldwide.
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